Solutions Of Rickets Disease 3 Chem Multiple Choice Questions?

3 chem multiple choice questions? - solutions of rickets disease

Hydrophobic interactions in a protein can occur between R-groups, that these amino acids?


D and W

R and H

F & O

V and N

None of these answers



The vitamin D receptor (VDR) binds specifically and narrowly, the steroid hormone 1a, 25 (OH) 2-vitamin D3 by the interaction of hydrogen bond between S237 for the 1a-OH-and H-307 for 25 - OH. It is a genetic disease in humans as resistant rickets, which occurs when a mutation in the amino acid sequence of the VDR S237 is mutated to F237. What can the consequences of the mutant VDR binding to 1A OH 25 predict () 2-vitamin A to the F237?


The reduction in binding of 1,25 D significantly VDRDue to the loss of a key hydrophobic interactions.

The binding of 1,25 D VDR is reduced because the loss of a key hydrogen bond

The binding of 1,25 D would be partially enhanced by the presence of F.

The binding of 1,25 D to VDR is not changed, but also the spatial structure of the VDR would be radically changed.

None of these answers



Consider a biochemical reaction that a large amount of hydrogen ions produced and will be conducted at a pH of 6.8. Only two acids are responsible for the preparation of the buffer solution. The pKa of acids A and B are 6.3 and 7.3, respectively. This would buffer the acid optimum for this reaction? Or in the water of reactionnot as good?


B-acid

An acid

Water

two acids would be equally effective

None of these answers